This is such a great overview of these drugs. I can speak from experience (fat and T2 diabetic) that these meds are ROUGH! I took the oral version (Rybelsus) of Wegovy/Ozempic and within 5 months on it I had to come off due to suicidal ideations. The GI issues were miserable too, but SI was scary. I’m now on Mounjaro and GI side effects are still there. It’s frustrating.
I am convinced that semaglutide is going to go down with *glitazone diabetes drugs (thiazolidinediones such as Actos, Rezulin, & Avandia) as disasters that cause more problems and deaths than they "helped." Forcing a non-diabetic's pancreas to work harder for no other reason than weight loss is not going to be healthy long term. And of course it makes sense that the effects are only temporary, given that making a non-diabetic have more insulin in the blood stream (or a diabetic having more insulin than needed) is going to promote weight gain, added to the risks of all sorts of health problems caused by the mechanisms itself.
Note that some *glitazone drugs are still available in the US, and other places, though in the US they come with black box warnings for potential congestive heart failure and liver problems, the latter being why Rezulin was pulled off the market.
This was a great overview of these drugs, thank you!
The only thing I’m confused about is your pointing out that the clinical trials for FDA approval of the drugs were conducted and funded by the drug companies. That is standard practice, not something unusual or underhanded, isn’t it? I have never known a pharma company to NOT conduct its own clinical trials, but maybe I am missing something?
This is such a great overview of these drugs. I can speak from experience (fat and T2 diabetic) that these meds are ROUGH! I took the oral version (Rybelsus) of Wegovy/Ozempic and within 5 months on it I had to come off due to suicidal ideations. The GI issues were miserable too, but SI was scary. I’m now on Mounjaro and GI side effects are still there. It’s frustrating.
I am convinced that semaglutide is going to go down with *glitazone diabetes drugs (thiazolidinediones such as Actos, Rezulin, & Avandia) as disasters that cause more problems and deaths than they "helped." Forcing a non-diabetic's pancreas to work harder for no other reason than weight loss is not going to be healthy long term. And of course it makes sense that the effects are only temporary, given that making a non-diabetic have more insulin in the blood stream (or a diabetic having more insulin than needed) is going to promote weight gain, added to the risks of all sorts of health problems caused by the mechanisms itself.
Note that some *glitazone drugs are still available in the US, and other places, though in the US they come with black box warnings for potential congestive heart failure and liver problems, the latter being why Rezulin was pulled off the market.
This was a great overview of these drugs, thank you!
The only thing I’m confused about is your pointing out that the clinical trials for FDA approval of the drugs were conducted and funded by the drug companies. That is standard practice, not something unusual or underhanded, isn’t it? I have never known a pharma company to NOT conduct its own clinical trials, but maybe I am missing something?
This was so helpful! 👏